Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Constitutive and Regulated Gene Expression01:27

Constitutive and Regulated Gene Expression

Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...
Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
Operon Model01:23

Operon Model

The operon model represents a fundamental mechanism of gene regulation in prokaryotes, enabling coordinated expression of genes involved in related metabolic or functional pathways. Operons consist of structural genes, a promoter, and an operator, with transcription regulated by repressors, activators, and small effector molecules.Structure and Function of OperonsAn operon is a cluster of structural genes transcribed together under the control of a single promoter. The promoter region...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Declining demands or constraining supply? Explaining the trend of care home entry in England 2001-2021.

The journals of gerontology. Series B, Psychological sciences and social sciences·2026
Same author

Induction of broadly neutralizing HIV antibodies by a two-step mechanism informs vaccine design.

Science (New York, N.Y.)·2026
Same author

Fast, long-range intercellular signal propagation through growth-assisted positive feedback.

Cell systems·2026
Same author

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development.

Science immunology·2026
Same author

Engineering plasmids with synthetic origins of replication.

Nature communications·2026
Same author

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design.

bioRxiv : the preprint server for biology·2025
Same journal

The hydra and hormetic effects in a single discrete-time overcompensation model.

Mathematical biosciences·2026
Same journal

Seasonal impacts on brucellosis transmission mediated by live sheep supply-demand dynamics.

Mathematical biosciences·2026
Same journal

Optimal controls and cost-effectiveness analysis on the transmission dynamics of early blight disease in tomatoes.

Mathematical biosciences·2026
Same journal

Temperature-dependent dynamics and allee effect thresholds mediate fourfold cusp stability in biological control of invasive vectors.

Mathematical biosciences·2026
Same journal

Dynamics of a stochastic tumor-immune interaction system with an Ornstein-Uhlenbeck process.

Mathematical biosciences·2026
Same journal

Post-peak dynamics and epidemic overshoot in SIR-type frameworks.

Mathematical biosciences·2026
See all related articles

Related Experiment Video

Updated: May 25, 2026

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

Modeling synthetic gene oscillators.

Erin L O'Brien1, Elizabeth Van Itallie, Matthew R Bennett

  • 1Department of Biochemistry & Cell Biology, Rice Univeristy, 6100 Main St., Houston, TX, USA.

Mathematical Biosciences
|January 24, 2012
PubMed
Summary
This summary is machine-generated.

Synthetic gene oscillators are key for synthetic biology, enabling circuit engineering and testing gene regulation models. This review details mathematical modeling approaches and biological factors influencing oscillator dynamics.

More Related Videos

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions
07:59

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions

Published on: March 22, 2018

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

Related Experiment Videos

Last Updated: May 25, 2026

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions
07:59

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions

Published on: March 22, 2018

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

Area of Science:

  • Synthetic Biology
  • Systems Biology
  • Biophysics

Background:

  • Synthetic gene oscillators are fundamental tools in synthetic biology, serving as benchmarks for engineering synthetic gene circuits.
  • They are also crucial for theoretical investigations, providing platforms to test mathematical models of gene regulation dynamics.

Purpose of the Study:

  • To provide a comprehensive review of mathematical modeling approaches for synthetic gene oscillators.
  • To elucidate the biological processes that impact the dynamics of gene regulation in these systems.

Main Methods:

  • Detailed examination of the derivation of mathematical models for synthetic gene oscillators.
  • Analysis of various approximation schemes and levels of biological detail in existing models.
  • Review of biological factors influencing gene regulatory dynamics.

Main Results:

  • Identification of diverse mathematical modeling strategies, differing in biological complexity and approximations.
  • Understanding how specific biological processes contribute to the dynamic behavior of synthetic gene oscillators.
  • Framework for analyzing and comparing different modeling approaches.

Conclusions:

  • Mathematical models are essential for understanding synthetic gene oscillator behavior.
  • The choice of model complexity and biological detail significantly impacts the prediction of dynamics.
  • This review offers insights into the interplay between modeling and biological reality in synthetic gene circuit design.