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Related Experiment Video

Updated: May 25, 2026

Control of Eating Behavior Using a Novel Feedback System

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

Cognitive and neuronal systems underlying obesity.

Scott E Kanoski¹

¹University of Pennsylvania, Department of Psychology, Philadelphia, PA 19104, United States. kanoski@sas.upenn.edu

Physiology & Behavior

|January 24, 2012

Summary

Obesity is driven by hyperphagia, or overeating, linked to environmental food cues and learning. The hippocampus plays a role in controlling this non-homeostatic food intake, but Western diets impair this function.

Area of Science:

Neuroscience
Cognitive Science
Obesity Research

Background:

Obesity prevalence and food intake have risen significantly in the USA since the late 1970s.
Hyperphagia, or overeating, drives obesity by increasing caloric intake beyond metabolic needs.
Environmental cues from energy-dense, nutrient-poor foods contribute to increased meal and snack frequency.

Purpose of the Study:

To examine the mechanisms by which food-related cues stimulate excessive energy intake.
To discuss learning and memory principles and their neuronal substrates in stimulus-driven food intake.
To highlight the hippocampus's role in modulating feeding behavior based on interoceptive cues.

Main Methods:

Review of learning and memory principles related to feeding behavior.

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Last Updated: May 25, 2026

Control of Eating Behavior Using a Novel Feedback System

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Published on: May 8, 2018

Fat Preference: A Novel Model of Eating Behavior in Rats

Fat Preference: A Novel Model of Eating Behavior in Rats

Published on: June 27, 2014

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

Discussion of neuronal substrates, particularly the hippocampus.

Analysis of how dietary factors impact hippocampal function and feeding control.

Main Results:

The hippocampus modulates stimulus-driven food intake using interoceptive cues like leptin.
Consumption of Western diets (high saturated fats, simple carbohydrates) compromises hippocampal-dependent feeding control.
Understanding these mechanisms is crucial for developing effective obesity treatments.

Conclusions:

Excessive food intake is influenced by a complex interplay of cognitive, environmental, dietary, and neurophysiological factors.
The hippocampus is a key brain structure involved in regulating non-homeostatic feeding.
Targeting the interaction between diet and hippocampal function may offer novel obesity treatment strategies.