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Non-invasive methods for quantitating bone loss of aging.

C C Johnston¹, C W Slemenda

¹Indiana University School of Medicine, Indianapolis 46202.

Experimental Gerontology

|January 1, 1990

Summary

Bone mass measurements predict fracture risk and guide therapeutic decisions, establishing clinical utility in specific cases. Further research is needed to confirm their role in widespread screening.

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Area of Science:

Osteoporosis research
Clinical diagnostics

Background:

The clinical utility of bone mass measurements is debated.
Determining utility requires predictive power, therapeutic options, and unique information.

Purpose of the Study:

To evaluate the clinical utility of bone mass measurements.
To assess if bone mass measurements predict clinical outcomes and guide therapy.

Main Methods:

Review of recent studies on bone mass measurements and fracture incidence.
Analysis of therapeutic options influenced by bone mass data.
Assessment of the uniqueness of information provided by bone mass measurements compared to other risk factors.

Main Results:

Bone mass measurements predict both non-spine and vertebral fractures.
Estrogen replacement therapy effectiveness is documented; other therapies may be influenced by bone mass.
Alternative risk factors have not adequately substituted bone mass measurements for prediction or risk estimation.

Conclusions:

Bone mass measurements show established clinical utility in specific circumstances.
Widespread screening utility is not yet definitively proven.
Further validation is needed to solidify the role of bone mass measurements in clinical practice.

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