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Updated: May 25, 2026

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection

Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection

Published on: December 19, 2025

GPCRs and cancer.

Rosamaria Lappano¹, Marcello Maggiolini

¹Department of Pharmaco-Biology, University of Calabria, Rende, Italy.

Acta Pharmacologica Sinica

|January 24, 2012

Summary

G-protein-coupled receptors (GPCRs) are key in cell signaling and cancer. This review explores how GPCRs influence tumor growth and metastasis, offering insights for new cancer therapies.

Area of Science:

Molecular Biology
Oncology
Pharmacology

Background:

G-protein-coupled receptors (GPCRs) constitute the largest human gene family.
GPCRs mediate physiological functions and are implicated in tumor growth and metastasis.
These receptors transduce signals from various molecules like hormones and neurotransmitters.

Purpose of the Study:

To review emerging information on GPCR-mediated responses in cancer.
To elucidate molecular mechanisms of GPCR action in cancer progression.
To identify novel pharmacological targets for cancer treatment.

Main Methods:

Literature review of GPCRs in cancer biology.
Analysis of signaling pathways modulated by GPCRs.
Examination of GPCRs' role in tumor cell activity.

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Published on: July 3, 2013

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Standardized SDS-PAGE Workflow for Personalized Protein Corona Profiling in Early Cancer Detection

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A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells

A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells

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Main Results:

GPCRs play a significant role in tumor growth and metastasis.
Integrated signaling networks involving GPCRs are crucial for tumor development.
Specific GPCRs exert primary actions in cancer progression.

Conclusions:

GPCRs are critical regulators of cancer progression.
Understanding GPCR mechanisms can lead to novel therapeutic strategies.
Targeting GPCRs offers potential for improved cancer patient outcomes.