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Updated: May 25, 2026
10:25
Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
Published on: December 12, 2019
Notch signalling in smooth muscle cells during development and disease
Charles Fouillade1, Marie Monet-Leprêtre, Céline Baron-Menguy
1INSERM, U740, Faculté de Médecine Paris 7, Site Villemin, 10 av de Verdun, Paris F-75010, France.
Cardiovascular Research
|January 24, 2012
Summary
The Notch signalling pathway is crucial for blood vessel development and function. This review details its role in smooth muscle cells and links it to vascular diseases like Alagille syndrome.
Area of Science:
- Vascular Biology
- Cell Signalling
- Developmental Biology
Background:
- The Notch signalling pathway is a conserved mechanism vital for organ development.
- Notch pathway components are present in vertebrate vasculature, indicating a key role.
- Previous research underscores the Notch pathway's importance in vascular development and physiology.
Purpose of the Study:
- To review the role of Notch signalling in vascular smooth muscle cells.
- To summarize Notch's contribution to vascular development and physiology.
- To discuss the clinical relevance of Notch signalling in vascular diseases.
Main Methods:
- Literature review of studies on Notch signalling in the vasculature.
- Focus on Notch's role in smooth muscle cells.
- Examination of clinical implications in vascular pathologies.
Main Results:
- Notch signalling is critical for smooth muscle cell function in blood vessels.
- Dysregulation of Notch contributes to vascular development and maturation issues.
- The pathway is implicated in diseases such as CADASIL, Alagille syndrome, and PAH.
Conclusions:
- Notch signalling is essential for vascular smooth muscle cell development and function.
- Understanding Notch's role offers insights into vascular diseases.
- Targeting Notch signalling may hold therapeutic potential for vascular conditions.
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03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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