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Updated: May 25, 2026

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Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients
Published on: October 11, 2024
Unilateral versus bilateral upper limb exercise therapy after stroke: a systematic review
A E Q van Delden1, C E Peper, Peter J Beek
1Faculty of Human Movement Sciences, VU University Amsterdam, Van der Boechorststraat, Amsterdam, The Netherlands. l.van.delden@vu.nl
Journal of Rehabilitation Medicine
|January 24, 2012
Summary
Unilateral and bilateral training show similar effectiveness for upper limb function after stroke. However, outcomes may depend on the severity of limb weakness and the timing of the intervention post-stroke.
Area of Science:
- Neurorehabilitation
- Stroke recovery
- Upper limb function
Background:
- Stroke frequently causes upper limb paresis, impacting daily activities.
- Rehabilitation strategies include unilateral and bilateral training.
- Optimal training approach requires further investigation based on patient-specific factors.
Purpose of the Study:
- To compare unilateral and bilateral training effects on upper limb function post-stroke.
- To investigate the influence of paresis severity and intervention timing on training effectiveness.
Main Methods:
- Systematic review and meta-analysis of randomized controlled trials.
- Independent selection, quality assessment, and data extraction by two authors.
- Pooled analysis using standardized mean differences (SMD) and mean differences (MD).
Main Results:
- Analysis of 9 studies with 452 patients revealed homogeneous results.
- Unilateral training showed marginally significant benefits in upper limb activity performance and perceived use/quality of movement for chronic patients with mild paresis.
- All other comparisons between unilateral and bilateral training yielded non-significant results.
Conclusions:
- Unilateral and bilateral training demonstrate comparable efficacy for upper limb function post-stroke.
- Intervention success is potentially modulated by the severity of upper limb paresis.
- The time of intervention post-stroke may also influence rehabilitation outcomes.

