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A novel high electrode count spike recording array using an 81,920 pixel transimpedance amplifier-based imaging chip.

Lee J Johnson¹, Ethan Cohen, Doug Ilg

¹Code 5611, Optical Sciences Division, Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375, USA. ljohnson@nrl.navy.mil

Journal of Neuroscience Methods

|January 24, 2012

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We developed a novel picocurrent imaging array (PIA) with 81,920 pixels for high-density neural recordings. This high-resolution system enables detailed study of neuronal activity across broader brain regions with excellent signal quality.

Area of Science:

Neuroscience
Bioengineering
Signal Processing

Background:

Current microelectrode arrays (60-100 electrodes) limit the study of neuronal function in large brain areas.
Higher density, larger area recording arrays are crucial for understanding complex neural circuits.

Purpose of the Study:

To introduce a novel high electrode count picocurrent imaging array (PIA) for advanced neural recordings.
To demonstrate the PIA's capability for high-speed, high-fidelity recording of neuronal biopotentials.

Main Methods:

Adapted an 81,920-pixel camera chip (Indigo ISC9809) for neural recording by bonding it to microwire glass.
Integrated low-noise transimpedance amplifiers (∼0.32 pA rms) at each pixel for high signal-to-noise ratio biocurrent recording.
Utilized selective subarray sampling for high-speed recording of neural activity.

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Main Results:

Achieved an inter-electrode pixel spacing of 30 μm for high-density recordings.
Recorded extracellular biocurrents of rabbit retinal ganglion cell spikes at 7.2 kHz sampling rates.
Captured full array local electroretinogram currents at 100 Hz frame rates, demonstrating broad applicability.

Conclusions:

The novel PIA offers a significant advancement for large-scale neural recordings.
Its high density, speed, and signal quality are suitable for studying complex neural systems.
Future iterations could cover 1cm areas, acquiring data from 1024 electrodes simultaneously at high sampling rates.