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A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
Exercise training decreases adipose tissue inflammation in cachectic rats.
F S Lira1, A S Yamashita, J C Rosa
1Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|January 24, 2012
Summary
Cancer cachexia causes inflammation in white adipose tissue. Moderate intensity exercise training helps reduce this inflammation and improve the anti-inflammatory cytokine balance in cachectic rats.
Area of Science:
- Oncology
- Exercise Physiology
- Immunology
Background:
- Cancer cachexia is linked to chronic systemic inflammation.
- Endurance training is a potential nonpharmacological anti-inflammatory intervention.
- White adipose tissue plays a role in systemic inflammation.
Purpose of the Study:
- To investigate the impact of moderate-intensity exercise on pro- and anti-inflammatory cytokine balance in white adipose tissue depots of cachectic rats.
- To evaluate the effects of exercise on inflammatory cell infiltration in adipose tissue during cancer cachexia.
Main Methods:
- Eight weeks of moderate-intensity treadmill exercise (60% VO2max) in tumor-bearing rats (Walker-256 carcinosarcoma).
- Analysis of retroperitoneal (RPAT) and mesenteric (MEAT) adipose tissue for cytokine mRNA (RT-PCR) and protein (ELISA) expression (IL-1β, IL-6, TNF-α, IL-10).
- Assessment of infiltrating monocyte counts in adipose tissue.
Main Results:
- Cachectic rats exhibited increased pro-inflammatory cytokines (TNF-α) in MEAT and elevated cytokine expression in RPAT compared to controls.
- The anti-inflammatory IL-10/TNF-α ratio was reduced in RPAT of cachectic rats, indicating inflammation.
- Exercise training improved the IL-10/TNF-α ratio and reduced monocyte infiltration in both MEAT and RPAT of cachectic rats.
Conclusions:
- Cancer cachexia is associated with white adipose tissue inflammation.
- Exercise training can prevent adipose tissue inflammation in the mesenteric depot and partially in the retroperitoneal depot.
- Exercise modulates the cytokine balance and reduces inflammatory cell infiltration in adipose tissue during cancer cachexia.
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