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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

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P53-induced protein with a death domain (PIDD): master of puppets?

F J Bock1, L Peintner, M Tanzer

  • 1Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria.

Oncogene
|January 24, 2012
PubMed

Insights

The P53-induced protein with a death domain (PIDD) plays a subtle role in DNA damage response, fine-tuning cell fate decisions and nuclear functions. Its precise physiological functions are still being uncovered, despite initial studies.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • P53-induced protein with a death domain (PIDD) is a p53 target gene activated by DNA damage.
  • Its exact physiological role in DNA damage response remains unclear, as PIDD knockout mice show no obvious phenotype.
  • PIDD has demonstrated in vitro capabilities in regulating cell life-death decisions.

Purpose of the Study:

  • To integrate current observations on PIDD's functions.
  • To propose potential unexplored roles for PIDD in cellular processes.

Main Methods:

  • Literature review and data integration.
  • Analysis of existing studies on PIDD function.

Main Results:

  • PIDD contributes to fine-tuning DNA damage response.
  • PIDD orchestrates caspase activation and NF-κB translocation.
  • PIDD exhibits nuclear functions, including modulation of translesion synthesis.

Conclusions:

  • PIDD's role extends beyond simple cell death execution.
  • PIDD is a key modulator of DNA damage response pathways.
  • Further research is needed to fully elucidate PIDD's nuclear and cellular functions.

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