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[A pharmacological analysis of the cholinergic system in animals with alloxan diabetes]
Farmakologiia I Toksikologiia
|July 1, 1990
Abstract:
In the animal experiment the sensitivity to acetylcholine was shown to increase in alloxan-induced hypoinsulinemia. The blockade of M-cholinoreactive structure produced by administration of amizil caused a deterioration of the condition of the animals with alloxan-induced diabetes. The increased sensitivity to acetylcholine was accompanied by changes in the activity of acetylcholine esterase in the hypothalamus nuclei.