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Revised structure of the peptide lactone antibiotic, TL-119 and/or A-3302-B
1Laboratory of Biochemistry, Faculty of Science, Kyushu University, Fukuoka, Japan.
FEBS Letters
|September 17, 1990
Abstract:
The peptide lactone antibiotic TL-119 and/or A-3302-B was chemically synthesized in order to confirm the proposed structure. The synthetic compound was different from both natural TL-119 and A-3302-B in their physicochemical properties and in biological activity. Re-examination of the configuration of the constituent amino acid residues in natural TL-119 and/or A-3302-B indicated that natural TL-119 and A-3302-B contains D-aThr instead of the original L-Thr. We tentatively propose a revised structure for TL-119 and/or A-3302-B.