Related Experiment Video

Updated: May 25, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
06:45

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

Vascular complications of Ehlers-Danlos syndrome: CT findings

Linda C Chu1, Pamela T Johnson, Harry C Dietz

  • 1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 601 N Caroline St, JHOC 3254, Baltimore, MD 21287, USA.

AJR. American Journal of Roentgenology
|January 24, 2012
PubMed

Insights

Vascular Ehlers-Danlos syndrome patients often experience early vascular issues. CT scans reveal aneurysms and dissections, prompting a shift towards earlier surgical intervention in some cases.

Area of Science:

  • Vascular Medicine
  • Radiology
  • Genetics

Background:

  • Vascular Ehlers-Danlos syndrome (vEDS) is a rare genetic connective tissue disorder.
  • Patients with vEDS are at high risk for life-threatening vascular complications, including arterial dissections and aneurysms.
  • Early diagnosis and management are crucial for improving patient outcomes.

Purpose of the Study:

  • To review computed tomography (CT) imaging findings in patients with vascular Ehlers-Danlos syndrome.
  • To discuss current management strategies for vascular abnormalities in vEDS.
  • To highlight the evolving approach to surgical intervention.

Main Methods:

  • Review of relevant literature on vEDS and vascular pathology.
  • Analysis of characteristic CT findings in vEDS patients.
  • Discussion of contemporary treatment guidelines and case examples.

Main Results:

  • Vascular complications in vEDS commonly affect multiple arterial segments.
  • Aneurysms and arterial dissections are the most frequent imaging findings on CT.
  • Imaging plays a critical role in identifying disease extent and guiding management.

Conclusions:

  • Vascular Ehlers-Danlos syndrome presents with widespread vascular involvement, primarily aneurysms and dissections.
  • The management paradigm is shifting from conservative care to earlier surgical consideration in select vEDS patients.
  • Multidisciplinary care and advanced imaging are essential for optimal vEDS management.
Abstract

More Related Videos

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane08:05

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Published on: December 9, 2022

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

Cardiovascular System Abnormal Findings I: Inspection and Palpation

In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
Esophageal Varices-I: Introduction01:24

Esophageal Varices-I: Introduction

Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...