Related Experiment Video
Updated: May 25, 2026
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
Choosing the right stimulation protocol for in vitro fertilization-embryo transfer in poor, normal, and
Purpose:
To describe the advantages of low-dose stimulation for poor responders, the pros and cons of low dose vs high dose stimulation for normal responders and multiple strategies for hyper-responders especially to reduce the risk of the ovarian hyperstimulation protocol.
Methods:
Various strategies are described for these three types of responders.
Results:
Poor responders do best with mild stimulation protocols. Conventional stimulation protocols for normal responders have the advantage of providing embryos for future embryo transfers assuming the IVF center has a good cryopreservation program. Mild stimulation protocols save money for normal responders. There are many strategies for hyper-responders to prevent ovarian hyperstimulation syndrome including mild stimulation, high LH/FSH ratio for stimulation combination, GnRH agonist instead of hCG and using clomiphene citrate or aromatase inhibitors.
Conclusions:
It is important to choose the right protocol for a given patient. An infertile couple can often help in making the decision.
