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Updated: May 25, 2026

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells

Published on: February 4, 2021

Inflammatory cells in node-negative breast cancer.

Britta Löfdahl¹, Cecilia Ahlin, Marit Holmqvist

¹Department of Oncology and Pathology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.

Acta Oncologica (Stockholm, Sweden)

|January 25, 2012

Summary

The amount of inflammatory cells in invasive breast cancer did not impact patient survival in node-negative cases. This study found no significant difference in inflammatory cell presence between patients who died from breast cancer and controls.

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Area of Science:

Oncology
Immunology
Pathology

Background:

Investigating the role of tumor-infiltrating inflammatory cells in breast cancer prognosis.
Focus on a well-defined cohort of women with node-negative breast cancer.

Purpose of the Study:

To determine the impact of inflammatory cell infiltration on survival in node-negative breast cancer.
To analyze correlations between different inflammatory cell subsets and clinicopathological factors.

Main Methods:

Nested case-control study design with 190 breast cancer deaths (cases) and 190 matched living controls.
Inclusion criteria: tumor size ≤ 50 mm, no lymph node metastases, no adjuvant chemotherapy.
Immunohistochemistry for CD3, CD4, CD8, FoxP3, CD20, tryptase, CD68; correlation analysis with clinicopathological variables.

Main Results:

No significant difference in the amount or type of inflammatory cells between cases and controls.
Strong correlation between T-cells and B-cells; weaker correlations with macrophages and no correlation with mast cells.
Weak correlations observed between inflammatory cell subsets and histological grade, Ki67, and cyclin A; negative correlation for mast cells.

Conclusions:

Inflammatory cell infiltration does not appear to influence mortality in node-negative invasive breast cancer.
Further research may be needed to elucidate the complex role of specific inflammatory cell types in breast cancer progression.