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Updated: May 25, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
Default mode network and extrastriate visual resting state network in patients with Parkinson's disease dementia
I Rektorova1, L Krajcovicova, R Marecek
1Applied Neurosciences Research Group, Central European Institute of Technology, CEITEC, Masaryk University, Brno, Czech Republic. irena.rektorova @ fnusa.cz
Aims:
Using fMRI, we evaluated the default mode network (DMN) and the extrastriate visual resting state network (ESV-RSN) in 14 patients with Parkinson's disease dementia (PDD) as compared with 18 patients with Parkinson's disease (PD) without dementia and 18 healthy controls (HC).
Methods:
We analyzed the seed-based functional connectivity of both resting state data and deactivations during a visual complex scene-encoding task.
Results:
Using the posterior cingulate cortex/precuneus as a seed for the DMN analysis, we observed significant decreases of connectivity in the right inferior frontal gyrus in PDD as compared to PD and HC. Using the caudate nucleus as a seed for the ESV-RSN analysis, we found significant decreases of connectivity in the left and right inferior occipital gyrus in PDD as compared to HC.
Conclusion:
Differences in functional connectivity patterns between PDD and PD/HC were observed in areas known to be engaged in stimulus-driven reorienting of attention and in visual processing.
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