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Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
Quorum sensing in plaque biofilms: challenges and future prospects
Baswaraj Biradar1, Prapulla Devi
1Department of Prosthodontics, Indira Gandhi Institute of Dental Sciences, Puducherry, India. impressioncare@gmail.com
The Journal of Contemporary Dental Practice
|January 25, 2012
Summary
Quorum sensing allows bacteria in biofilms to communicate and coordinate activities. Interfering with this bacterial communication offers promising new strategies for preventing and treating dental caries and periodontal disease.
Area of Science:
- Microbiology
- Molecular Biology
- Biotechnology
Background:
- Dental plaque biofilms are linked to periodontal disease and dental caries.
- Quorum sensing (QS) is a cell-to-cell communication mechanism used by bacteria in biofilms.
- QS regulates various bacterial activities, making it a target for therapeutic intervention.
Purpose of the Study:
- To review quorum sensing in bacterial biofilms.
- To explore new research on interfering with bacterial quorum sensing.
- To highlight the potential of QS interference in combating oral diseases.
Main Methods:
- Literature review of in vitro studies on bacterial quorum sensing.
- Analysis of natural and synthetic methods for manipulating QS.
- Identification of QS signal machinery in microbial communities.
Main Results:
- Quorum sensing is crucial for bacterial communication and behavior regulation in biofilms.
- Studies have identified the basic cell-cell signaling machinery used by bacteria.
- Various methods for interfering with bacterial QS have been investigated.
Conclusions:
- Interfering with bacterial quorum sensing presents a promising avenue for novel therapeutic strategies.
- Further research is needed to develop effective QS interference mechanisms for oral diseases.
- Understanding bacterial communication in biofilms opens prospects for treating biofilm-related diseases.
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