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Related Experiment Video

Updated: May 25, 2026

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution

Imaging Cleared Embryonic and Postnatal Hearts at Single-cell Resolution

Published on: October 7, 2016

Primitive neuroectodermal tumor of the heart.

Nnamdi Nwaejike¹, Doris Rassl, Hugo Ford

¹Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, United Kingdom.

The Annals of Thoracic Surgery

|January 25, 2012

Summary

A rare primitive neuroectodermal tumor in the left atrium, causing cardiac tamponade, was successfully resected. The patient remains tumor-free at two years without chemotherapy, highlighting a potentially curative surgical approach.

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Area of Science:

Cardiovascular Pathology
Pediatric Oncology
Surgical Oncology

Background:

Primitive neuroectodermal tumors (PNETs) are rare, aggressive neoplasms with diverse origins.
Cardiac PNETs are exceptionally uncommon, posing diagnostic and therapeutic challenges.
This case explores a PNET arising primarily within the left atrium.

Observation:

A patient presented with cardiac tamponade due to a large left atrial mass.
Imaging confirmed a solitary tumor involving the left atrium and coronary sinus.
No distant metastases were detected, suggesting a localized primary cardiac tumor.

Findings:

Complete surgical resection of the left atrial PNET was achieved.
The patient experienced a favorable outcome with no tumor recurrence at 2-year follow-up.
Adjuvant chemotherapy was not administered, distinguishing this case from others in the literature.

Implications:

Complete surgical resection may be a viable curative strategy for localized cardiac PNETs.
This case challenges the necessity of adjuvant chemotherapy in select instances of cardiac PNET.
Further research is warranted to define optimal treatment paradigms for rare cardiac tumors.