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Botulinum toxin therapy in dysthyroid strabismus
C J Lyons1, S F Vickers, J P Lee
1Moorfields Eye Hospital, London.
Eye (London, England)
|January 1, 1990
Summary
Botulinum toxin injections effectively reduced eye deviation in severe dysthyroid strabismus patients. This treatment offers temporary binocularity and may indicate inflammatory spasm rather than contracture.
Area of Science:
- Ophthalmology
- Neurology
Background:
- Dysthyroid strabismus, a common complication of thyroid eye disease, often requires surgical intervention.
- Botulinum toxin is explored as a non-surgical option for managing strabismus.
Observation:
- A study involved 38 patients (64 injections) with severe dysthyroid strabismus.
- Botulinum toxin injections were administered to assess their efficacy and impact on eye deviation.
Findings:
- Approximately 75% of injections resulted in a significant reduction (mean 75%) of the squint angle.
- The therapeutic effect lasted an average of two months.
- Six patients achieved long-term stability with Botulinum toxin alone, while 26 proceeded to surgery after stabilization.
Implications:
- The findings suggest Botulinum toxin may be a valuable temporary measure for maintaining binocularity in early dysthyroid myopathy.
- Results support the hypothesis that early dysthyroid myopathy presents as inflammatory spasm rather than contracture.
- Botulinum toxin offers a potential non-surgical management strategy, delaying or avoiding surgery in select cases.