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Updated: May 25, 2026

Murine Bilateral Renal Lymphadenectomy

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Plasmapheresis in immunologic renal disease.

Charles D Pusey¹, Jeremy B Levy

¹Renal Section, Department of Medicine, Imperial College London, London, UK. c.pusey @ imperial.ac.uk

Blood Purification

|January 25, 2012

Summary

Plasmapheresis removes harmful immune substances from the blood to treat kidney diseases. This review summarizes its current uses in immunologic renal conditions, supported by growing evidence from controlled trials.

Area of Science:

Nephrology
Immunology
Transplantation

Background:

Plasmapheresis has been utilized for immunologic renal disease management for four decades.
The core principle involves removing circulating pathogenic immune mediators like autoantibodies and immune complexes.
Potential benefits include depletion of proinflammatory molecules such as complement and coagulation factors.

Purpose of the Study:

To review and summarize the current clinical indications for plasmapheresis in immunologic renal diseases.
To highlight the evolving role of plasmapheresis based on recent randomized controlled trials.

Main Methods:

Review of historical and recent literature on plasmapheresis in nephrology.
Analysis of evidence from uncontrolled studies and randomized controlled trials.

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Optical Clearing and Imaging of Immunolabeled Kidney Tissue

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Murine Bilateral Renal Lymphadenectomy

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Optical Clearing and Imaging of Immunolabeled Kidney Tissue

Optical Clearing and Imaging of Immunolabeled Kidney Tissue

Published on: July 22, 2019

Synthesis of data on plasmapheresis efficacy in various immunologic renal conditions.

Main Results:

Plasmapheresis is indicated for Goodpasture's disease, systemic vasculitis, and hemolytic uremic syndrome/thrombotic thrombocytopenic purpura.
It is also used in cryoglobulinemia and systemic lupus erythematosus for immune complex removal.
In renal transplantation, it treats antibody-mediated rejection and facilitates desensitization for incompatible transplants.

Conclusions:

Plasmapheresis remains a valuable therapeutic option for specific immunologic renal diseases.
Evidence from controlled trials supports its use in various conditions, including autoimmune diseases and transplantation.
The application of plasmapheresis continues to expand with ongoing research and clinical experience.