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Updated: May 25, 2026
Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons
Published on: August 16, 2020
A pilot study examining associations between DYRK1A and α-synuclein dementias
Emma L Jones1, Dag Aarsland, Elisabet Londos
1Wolfson Centre for Age-Related Disease, King's College London, Guy's Campus, London, UK. emma.3.jones@kcl.ac.uk
Background:
DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including α-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions.
Objective:
To determine if DYRK1A also has a genetic association with α-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease dementia.
Methods:
DNA samples from prospectively followed cohorts of control and dementia individuals were genotyped for the DYRK1A rs8126696 polymorphism.
Results:
The rs8126696 polymorphism altered the risk of developing an α-synuclein-associated dementia.
Conclusion:
DYRK1A could prove to be an important therapeutic target as it interacts with several proteins associated with the development of pathology in dementia.
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