Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Functions of the Lymphatic and Immune System

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...

Introduction to Lymphatic and Immune System

Introduction to Lymphatic and Immune System

Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...

Special Features of Adaptive Immunity

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gut microbiota modulates aversive learning and memory of honeybees (Apis mellifera).

Nature communications·2025

Same author

CPT1A inhibition alleviates plasmacytoid dendritic cell-mediated immune suppression in colon cancer through fatty acid oxidation modulation.

Journal for immunotherapy of cancer·2025

Same author

[Efficacy and safety of stem cell therapy for erectile dysfunction: A systematic review and Meta-analysis].

Zhonghua nan ke xue = National journal of andrology·2025

Same author

Metabolic Engineering of Acinetobacter baylyi ADP1 for L-Leucine Production.

Journal of basic microbiology·2025

Same author

<i>Myo-</i>inositol affects the health, metabolome, and lactation performance of peripartum dairy cows.

Frontiers in immunology·2025

Same author

Novel 3,4-dihydronaphthalen-1(2H)-one derivatives promote apoptosis and inhibit migration of hepatocellularcarcinoma cells via inhibition of NF-κB and MAPK signaling pathways.

European journal of medicinal chemistry·2025

Search research articles

Related Experiment Video

Updated: May 25, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

TSLP and immune homeostasis.

Shino Hanabuchi¹, Norihiko Watanabe, Yong-Jun Liu

¹Department of Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, TX 77004, USA. shanabuc@mdanderson.org

Allergology International : Official Journal of the Japanese Society of Allergology

|January 25, 2012

Summary

Thymic stromal lymphopoietin (TSLP) shapes dendritic cell (DC) function. This review explores how TSLP regulates T-cell development and homeostasis in lymphoid and non-lymphoid tissues.

More Related Videos

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

Related Experiment Videos

Last Updated: May 25, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

Area of Science:

Immunology
Cell Biology
Cytokine Signaling

Background:

Dendritic cells (DCs) are key antigen-presenting cells (APCs) that initiate immune responses.
The influence of the steady-state tissue microenvironment on DC function remains incompletely understood.
Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine known to activate DCs.

Purpose of the Study:

To review the regulatory role of TSLP in DC-mediated immune responses.
To elucidate how TSLP influences T-cell development and homeostasis.
To highlight the crosstalk between epithelial cells and DCs mediated by TSLP.

Main Methods:

Literature review of recent research on TSLP and DCs.
Analysis of TSLP's expression in various tissues.
Examination of TSLP's impact on T-cell development and peripheral T-cell homeostasis.

Main Results:

TSLP actively mediates communication between epithelial cells and DCs.
TSLP expression in the thymus and peripheral tissues regulates DC function.
TSLP is crucial for both T-cell development in the thymus and T-cell homeostasis in the periphery.

Conclusions:

TSLP plays a significant role in immune homeostasis by modulating DC function.
Understanding TSLP's mechanisms offers insights into immune regulation in both health and disease.
TSLP is a critical link between epithelial barrier integrity and adaptive immunity.