Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunotherapy for early-stage cutaneous squamous cell carcinoma.

Journal for immunotherapy of cancer·2026
Same author

A high-penetrance intergenic variant at 9p21 confers melanoma susceptibility.

Research square·2026
Same author

Discontinuation of combo immunotherapy and outcome of patients with melanoma brain metastases.

Journal for immunotherapy of cancer·2026
Same author

Dissecting the Spectrum of Rare BRAF Mutations in Melanoma: A Nation-Wide Study by the Italian Melanoma Intergroup (IMI).

Pigment cell & melanoma research·2026
Same author

Age-specific melanoma risk associated with nevi: a pooled analysis from the M-SKIP project.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

A phase 2 study of abemaciclib in patients with brain metastases secondary to non-small cell lung cancer or melanoma.

Neuro-oncology advances·2026

Related Experiment Video

Updated: May 25, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Uveal melanoma.

Francesco Spagnolo1, Graziano Caltabiano, Paola Queirolo

  • 1Department of Plastic and Reconstructive Surgery, National Institute for Cancer Research, Genova, Italy. francesco.spagnolo85@gmail.com

Cancer Treatment Reviews
|January 25, 2012
PubMed
Summary

Metastatic uveal melanoma lacks effective treatments. Researchers are exploring targeted therapies and immunotherapies like ipilimumab to improve survival for this rare eye cancer.

Area of Science:

  • Ophthalmology
  • Medical Oncology
  • Cancer Biology

Background:

  • Uveal melanoma is the most common primary adult intraocular tumor.
  • Metastasis occurs in up to 50% of patients, primarily to the liver, with poor median survival (4-5 months).
  • Effective systemic therapies for metastatic uveal melanoma are lacking due to intrinsic chemoresistance.

Purpose of the Study:

  • To review current and emerging treatment strategies for metastatic uveal melanoma.
  • To highlight the potential of targeted therapies and immunotherapies.

Main Methods:

  • Review of existing literature on uveal melanoma treatment.
  • Discussion of targeted agents (bevacizumab, imatinib, MEK-inhibitors) and immunotherapies (ipilimumab).

More Related Videos

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

Generation of a Liver Orthotopic Human Uveal Melanoma Xenograft Platform in Immunodeficient Mice
04:02

Generation of a Liver Orthotopic Human Uveal Melanoma Xenograft Platform in Immunodeficient Mice

Published on: November 6, 2019

Related Experiment Videos

Last Updated: May 25, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

Generation of a Liver Orthotopic Human Uveal Melanoma Xenograft Platform in Immunodeficient Mice
04:02

Generation of a Liver Orthotopic Human Uveal Melanoma Xenograft Platform in Immunodeficient Mice

Published on: November 6, 2019

Main Results:

  • Targeted therapies are under investigation as single agents or in combination.
  • Ipilimumab shows preliminary evidence of efficacy in ocular melanoma, similar to its effect in cutaneous melanoma.

Conclusions:

  • Novel therapeutic approaches, including targeted drugs and immunotherapies, are crucial for improving outcomes in metastatic uveal melanoma.
  • Further research is needed to establish the efficacy of these agents in clinical practice.