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Related Experiment Video

Updated: May 25, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Systemic mastocytosis complicating pregnancy.

Kendra D Watson1, Katherine W Arendt, William J Watson

  • 1From the South Dakota School of Medicine, Vermillion, South Dakota; and the Department of Anesthesiology, Maternal Fetal Medicine, and the Division of Allergy and Immunology, Mayo Clinic, Rochester, Minnesota.

Obstetrics and Gynecology
|January 25, 2012
PubMed
Summary

Systemic mastocytosis during pregnancy can cause severe complications for both mother and fetus. Prompt treatment with H1 blockers, steroids, and epinephrine can effectively manage these risks.

Area of Science:

  • Reproductive Medicine
  • Hematology
  • Allergy and Immunology

Background:

  • Systemic mastocytosis (SM) is a rare disorder characterized by increased mast cells, potentially causing severe hypersensitivity reactions.

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  • Elevated serum tryptase levels are a hallmark of SM.
  • Pregnancy with known SM has generally shown favorable outcomes, though complications can arise.