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Updated: May 25, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

Conjunctival nodule in rheumatoid arthritis.

Ahmad Kheirkhah¹, Fahimeh Asadi Amoli, Amir A Azari

¹Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Sciences, Qazvin Square, South Kargar Street, Tehran, Iran. Akheirkh@yahoo.com

International Ophthalmology

|January 25, 2012

Summary

Rheumatoid nodules can appear on the conjunctiva, the eye's surface, even without methotrexate use. This rare finding in rheumatoid arthritis patients may indicate disease severity.

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Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Area of Science:

Ophthalmology
Rheumatology
Pathology

Background:

Rheumatoid arthritis is a systemic autoimmune disease.
Conjunctival nodules are rare manifestations of rheumatoid arthritis.
Previous cases were linked to methotrexate treatment.

Observation:

A case of a conjunctival rheumatoid nodule in a patient with seropositive rheumatoid arthritis is presented.
The patient was treated with oral steroids and hydroxychloroquine, not methotrexate.
Anterior scleritis and a focal, raised conjunctival nodule were observed.

Findings:

The conjunctival nodule was a distinct lesion within the bulbar conjunctiva.
Histopathological examination revealed central necrosis surrounded by palisaded histiocytes.
The nodule's characteristics differed from nodular scleritis.

Implications:

Conjunctival rheumatoid nodules can occur independently of methotrexate therapy.
This ocular finding may signify underlying rheumatoid arthritis disease activity.
Aggressive treatment may be necessary for severe cases presenting with conjunctival nodules.