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Delayed CSF enhancement associated with Todd's paresis.

Hiroyuki Uetani1, Toshinori Hirai, Mika Kitajima

  • 1Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan. hama-moto@hotmail.co.jp

Japanese Journal of Radiology
|January 25, 2012
PubMed
Summary

Todd's paresis can cause gadolinium leakage into cerebrospinal fluid (CSF) after a lung biopsy. This leakage, seen on MRI, indicates increased permeability in the brain's lining.

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Area of Science:

  • Neurology
  • Radiology
  • Neurosurgery

Background:

  • Todd's paresis is a rare neurological condition.
  • Magnetic Resonance Imaging (MRI) is crucial for diagnosing neurological disorders.
  • Contrast agents like gadolinium enhance MRI visibility.

Observation:

  • A patient with Todd's paresis developed increased signal intensity in the subarachnoid space.
  • This observation was made on 10-hour delayed enhanced fluid-attenuated inversion recovery (FLAIR) MRI sequences.
  • The patient had recently undergone a lung biopsy.

Findings:

  • The observed MRI findings suggest gadolinium leakage into the cerebrospinal fluid (CSF).
  • This leakage is attributed to increased leptomeningeal microvascular permeability.
  • The permeability is likely associated with the patient's condition of Todd's paresis.

Implications:

  • This finding highlights a potential complication of gadolinium-based contrast agents in patients with Todd's paresis.
  • It underscores the importance of considering microvascular integrity in neurological conditions.
  • Further research may be needed to understand the long-term effects and management strategies.