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Interventions promoting adherence to cardiovascular medicines.

Judith van Dalem¹, Ines Krass, Parisa Aslani

¹Department of Pharmaceutical Sciences, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, FAFC Wentgebouw, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands. j.vandalem@students.uu.nl

International Journal of Clinical Pharmacy

|January 25, 2012

Summary

Behavioral interventions are most effective for improving adherence to cardiovascular medicines. Combining strategies may enhance outcomes, but long-term, multifaceted approaches are crucial for sustained medicine-taking in patients with cardiovascular diseases.

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Area of Science:

Pharmacology and Public Health
Cardiovascular Medicine
Health Behavior Research

Background:

Cardiovascular diseases (CVDs) pose a significant healthcare burden, with low medication adherence impacting treatment efficacy.
Optimizing adherence and persistence to cardiovascular medications is critical for improving patient health outcomes.
Identifying effective community-based interventions is essential for enhancing medication adherence in CVD patients.

Purpose of the Study:

To review literature on community-based interventions aimed at improving adherence to cardiovascular medicines.
To evaluate the effectiveness of different intervention strategies in patients with hypertension, dyslipidaemia, congestive heart failure, or ischaemic heart disease.

Main Methods:

A comprehensive literature search was conducted across multiple databases (Medline, EMBASE, etc.) for studies published between 1979 and 2009.
Eligible studies evaluated interventions to improve adherence to cardiovascular medicines in a community setting, including a comparison/control group.
Studies were categorized into informational, behavioural, social, and combined strategy interventions.

Main Results:

Out of 36 eligible studies, 17 reported significant improvements in medication adherence or persistence.
Behavioural interventions demonstrated the highest success rate in improving adherence compared to informational or social strategies.
While 21 studies showed improvements in clinical outcomes, these effects were variable and not consistently linked to adherence changes.

Conclusions:

Various interventions can effectively improve adherence and persistence to cardiovascular medicines in community settings.
Behavioural interventions are the most successful, with no additional benefit observed from combining informational strategies.
Sustained improvement in medication adherence requires long-term, multifaceted interventions addressing the dynamic nature of patient behavior.