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Updated: May 25, 2026

Experimental Human Pneumococcal Carriage
Published on: February 15, 2013
Advance market commitment for pneumococcal vaccines: putting theory into practice.
Tania Cernuschi1, Eliane Furrer, Nina Schwalbe
1GAVI Alliance Secretariat, 2 Chemin des Mines, Geneva, Switzerland.
The Advance Market Commitment (AMC) initiative successfully increased access to pneumococcal vaccines in low-income countries by mitigating market risks. Early lessons highlight challenges in long-term funding and design tailoring for vaccine market success.
Area of Science:
- Global Health
- Health Economics
- Vaccine Market Dynamics
Background:
- Market failures in low-income countries hinder access to essential vaccines.
- Underinvestment in vaccine development is driven by uncertain demand and funding.
- The Advance Market Commitment (AMC) pilot was launched to address these market failures.
Purpose of the Study:
- To evaluate early lessons from the pneumococcal vaccine AMC pilot.
- To analyze design choices and challenges in implementing the AMC.
- To inform future applications of market commitment concepts.
Main Methods:
- Case study analysis of the pneumococcal vaccine AMC pilot.
- Examination of AMC design choices and their impact.
- Assessment of challenges in establishing long-term commitments.
Main Results:
- 14 countries introduced pneumococcal vaccines via AMC, with 39 more expected by end of 2013.
- Demonstrated success in establishing a credible, long-term commitment despite environmental volatility.
- Highlighted the critical dependence on continuous donor funding for sustained vaccine procurement.
Conclusions:
- The AMC shows promise in improving vaccine access in low-income settings.
- Tailoring AMC design to specific vaccine markets is crucial.
- Sustainable donor funding is essential for the long-term viability of AMC initiatives.
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