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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Toxicogenomic biomarkers for liver toxicity
Naoki Kiyosawa1, Yosuke Ando, Sunao Manabe
1Medicinal Safety Research Labs., Daiichi Sankyo Co., Ltd., 717 Horikoshi, Fukuroi, Shizuoka 437-0065, Japan.
Journal of Toxicologic Pathology
|January 25, 2012
Summary
Toxicogenomics (TGx) aids drug development by identifying molecular toxicity mechanisms. This review focuses on liver TGx biomarkers from microarray analysis for improved drug safety assessment.
Area of Science:
- Pharmacology and Toxicology
- Biomarker Discovery
- Genomics
Background:
- Toxicogenomics (TGx) is crucial in preclinical drug development for understanding toxicity mechanisms.
- Identified TGx biomarkers aid in assessing and predicting drug toxicities.
- Advancements in TGx biomarker discovery enhance drug risk assessment efficiency and cost-effectiveness.
Purpose of the Study:
- To overview strategies and challenges in identifying and utilizing TGx biomarkers via microarray analysis.
- To focus on liver TGx studies due to hepatotoxicity being a major cause of drug development failure.
- To summarize existing literature on liver TGx studies for potential biomarker gene set extraction.
Main Methods:
- Review of existing literature on toxicogenomics studies, specifically focusing on liver toxicity.
- Analysis of microarray data for identifying potential TGx biomarkers.
- Extraction of TGx biomarker gene sets relevant to hepatotoxicity.
Main Results:
- Candidate TGx biomarkers have been identified and are used for toxicity assessment and prediction.
- Microarray analysis provides practical strategies and identifies obstacles for TGx biomarker utilization.
- The liver is the most documented organ for TGx studies, with available resources for biomarker discovery.
Conclusions:
- Further accumulation of novel TGx biomarkers will improve drug risk assessment.
- Understanding molecular mechanisms of drug-induced toxicity reinforces conventional toxicology.
- Toxicologists can utilize summarized liver TGx literature for enhanced hepatotoxicity risk assessment.
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