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Emphysematous cystitis in a chemically-induced diabetic dog
Saori Matsuo1, Shuji Hayashi, Takeshi Watanabe
1Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., 1-135 Komakado, Gotemba-shi, Shizuoka 412-8513, Japan.
Journal of Toxicologic Pathology
|January 25, 2012
Summary
Emphysematous cystitis, a rare bacterial bladder infection causing gas accumulation, was observed in a diabetic beagle. Histopathology revealed cyst formation lined by myofibroblasts, fibroblasts, or macrophages, with associated giant cells and bacteria.
Area of Science:
- Veterinary Pathology
- Uropathology
Background:
- Emphysematous cystitis is a rare bladder condition characterized by gas within the bladder wall, often linked to bacterial infection.
- Diabetic animal models are crucial for studying metabolic and infectious diseases.
Observation:
- A case of emphysematous cystitis in a streptozotocin and alloxan-induced diabetic female beagle is presented.
- Macroscopic examination revealed multiple cyst-like structures on the urinary mucosa, with specimens floating during fixation.
- Histopathology showed cysts lined by vimentin-positive cells (myofibroblasts, fibroblasts, or macrophages), multinucleated giant cells, and gram-negative bacilli.
Findings:
- The study details the histopathological features of emphysematous cystitis in a canine model.
- Immunohistochemistry identified specific cell types lining the cysts, suggesting a complex inflammatory and cellular response.
- The presence of gram-negative bacilli confirmed a bacterial etiology.
Implications:
- This case provides valuable histopathological insights into emphysematous cystitis in a diabetic animal model.
- Understanding the cellular mechanisms and causative agents can aid in diagnosing and managing this rare condition.
- The findings contribute to the comparative pathology of urinary tract infections and gas-forming bacterial diseases.
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