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Keratoconus in a cynomolgus monkey.

Rinya Kodama¹, Xiuying Yang, Tomoaki Araki

¹Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., 2438 Miyanoura, Kagoshima 891-1394, Japan.

Journal of Toxicologic Pathology

|January 25, 2012

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This study reports the first case of keratoconus in a cynomolgus monkey, characterized by corneal opacity and conical protrusion. Findings include significant pathological changes in the cornea

Area of Science:

Ophthalmology
Primate Research
Veterinary Pathology

Background:

Keratoconus is a progressive eye condition affecting the cornea.
Cynomolgus monkeys are valuable models in biomedical research.

Observation:

A seven-year-old male cynomolgus monkey presented with eyelid erythema and severe ocular abnormalities.
Clinical signs included corneal opacity, edema, and conical protrusion.
Necropsy revealed bilateral corneal opacity and protrusion, with elevated IgE levels.

Findings:

Histopathology showed corneal epithelial thinning, Bowman's membrane folding and loss, and stromal changes.
Electron microscopy revealed atrophy of corneal epithelial basal cells.
These pathological findings are consistent with keratoconus.

Keywords:

atopy-like mechanism cynomolgus monkey high serum IgE keratoconus

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Implications:

This case represents the first documented instance of keratoconus in a cynomolgus monkey.
This finding may impact non-human primate models in vision research.
Further investigation is needed to understand the etiology and prevalence in this species.