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Polyurethane-based microfluidic devices for blood contacting applications.

Wen-I Wu1, Kyla N Sask, John L Brash

  • 1Department of Mechanical Engineering, McMaster University, Hamilton, ON, Canada.

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Summary

New fabrication processes enable thin, transparent, and flexible polyurethane (PU) microfluidic devices. These devices show reduced protein adsorption, offering an alternative to polydimethylsiloxane (PDMS) for blood-contacting applications.

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Area of Science:

  • Biomaterials Science
  • Microfluidics Engineering
  • Surface Chemistry

Background:

  • Protein adsorption on polydimethylsiloxane (PDMS) is a major issue in microfluidic devices handling biofluids.
  • Polyurethane (PU) is suitable for medical devices but underutilized in microfluidics.

Purpose of the Study:

  • To develop novel fabrication methods for thin, transparent, and flexible PU microfluidic devices.
  • To improve biointerfacing properties of PU for microfluidic applications, specifically reducing protein adsorption.

Main Methods:

  • Developed two new fabrication processes for polyurethane microchannels.
  • Integrated fluidic interconnections and employed surface modification with polyethylene oxide (PEO).
  • Characterized microchannels for transparency, bond strength, and protein adsorption.

Main Results:

  • Achieved high transparency (96% of glass) and bond strength (326.4 kPa).
  • Demonstrated an 80% reduction in fibrinogen adsorption compared to unmodified PDMS.
  • Successfully created thin, transparent, and flexible PU-based microfluidic devices.

Conclusions:

  • PEO-modified PU microfluidic devices offer excellent optical and mechanical properties.
  • These devices significantly reduce protein adsorption, crucial for preventing biofouling.
  • PEO-modified PU presents a viable alternative to PDMS for blood-contacting microfluidic applications.