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Mn loaded apoferritin as an MRI sensor of melanin formation in melanoma cells
Ibolya Szabó1, Simonetta Geninatti Crich, Diego Alberti
1Center for Molecular Imaging, Department of Chemistry IFM, University of Torino, via Nizza 52, Torino, Italy.
Chemical Communications (Cambridge, England)
|January 26, 2012
Abstract:
Mn(III)-loaded apoferritin is promptly reduced to Mn(II)-apoferritin by the oxidation of L-DOPA to melanin. The process is nicely witnessed by a marked relaxation enhancement of water proton relaxation rate that has been detected both in cultured melanoma cells and in tumor animal models.
