Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Two-locus linkage analysis using recombinant inbred strains and Bayes' theorem.

P E Neumann1

  • 1Department of Neurology, Children's Hospital, Boston, Massachusetts.

Genetics
|September 1, 1990
PubMed
Summary

This study introduces a more stringent Bayesian analysis for linkage detection using recombinant inbred (RI) strains. The new method improves gene mapping accuracy and provides critical values for analyzing RI strain data.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Familial essential thrombocythemia with spontaneous megakaryocyte colony formation and acquired JAK2 mutations.

Leukemia·2008
Same author

Plasticity: downstream of glutamate.

Trends in neurosciences·2001
Same author

Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same author

Strain and sex differences in the morphology of the medial preoptic nucleus of mice.

The Journal of comparative neurology·2000
Same author

Absence of fragile X syndrome in Nova Scotia.

Journal of medical genetics·2000
Same author

ETn insertion in the mouse Adcy1 gene: transcriptional and phylogenetic analyses.

Mammalian genome : official journal of the International Mammalian Genome Society·2000

Area of Science:

  • Genetics
  • Bioinformatics
  • Statistical genetics

Background:

  • Recombinant inbred (RI) strains are valuable genetic tools for linkage analysis and gene mapping.
  • Existing statistical tests for RI strain data, including prior Bayesian methods, lack sufficient stringency for reliable linkage conclusions.

Purpose of the Study:

  • To develop a more statistically rigorous method for estimating the probability of linkage using Bayes' theorem with RI strain data.
  • To provide updated statistical tools and critical values for enhancing the power of RI strains in genetic analysis.

Main Methods:

  • Employed Bayes' theorem to estimate the probability of linkage.
  • Generated tables presenting the probability of linkage for up to 30 RI strains.
  • Calculated critical values for the number of recombinants (i) in up to 100 RI strains.

Related Experiment Videos

Main Results:

  • Presented a stringent Bayesian approach for linkage probability estimation in RI strains.
  • Provided comprehensive tables for analyzing linkage probabilities and critical recombinant values across various RI strain set sizes.
  • Identified strategies to augment the analytical power of RI strains.

Conclusions:

  • The proposed Bayesian method offers a more stringent and reliable approach to linkage analysis in RI strains.
  • The provided tables and critical values serve as essential resources for gene mapping studies.
  • Further discussion on enhancing RI strain power in linkage analysis is presented.