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Related Experiment Videos

Analgesia and haloperidol: a hypothesis.

A A Maltbie, J O Cavenar, J L Sullivan

    The Journal of Clinical Psychiatry
    |July 1, 1979
    PubMed
    Summary
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    Haloperidol may reduce or eliminate the need for narcotic analgesics in patients with intractable pain. Further research is exploring its use as an adjunctive treatment for cancer pain.

    Area of Science:

    • Pharmacology
    • Pain Management
    • Oncology

    Background:

    • Previous case reports suggest Haloperidol can reduce narcotic analgesic requirements in intractable pain syndromes.
    • Haloperidol's potential analgesic properties warrant further investigation, particularly in cancer pain management.

    Purpose of the Study:

    • To evaluate Haloperidol as an adjunctive treatment for intractable cancer pain in a controlled, double-blind study.
    • To explore the relationship between Haloperidol, Meperidine, and opiate receptor activity.

    Main Methods:

    • Conducting a controlled double-blind evaluation of Haloperidol.
    • Analyzing dose-response relationships between Haloperidol and analgesic effects.
    • Reviewing clinical literature on Haloperidol for narcotic addiction withdrawal and maintenance.

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    Main Results:

    • Previous observations indicate Haloperidol can significantly reduce or eliminate the need for narcotic analgesics.
    • The study aims to confirm these findings in a rigorous clinical trial setting.

    Conclusions:

    • Haloperidol shows promise as an adjunctive therapy for intractable cancer pain.
    • Further research is needed to elucidate the mechanisms underlying Haloperidol's analgesic effects, including its relationship to opiate receptors and structural similarities to Meperidine.