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Related Concept Videos

Attenuated Total Reflectance (ATR) Infrared Spectroscopy: Overview01:13

Attenuated Total Reflectance (ATR) Infrared Spectroscopy: Overview

Attenuated total reflectance (ATR) infrared spectroscopy is a powerful analytical technique used to study the composition of materials. It is widely employed in chemistry, materials science, forensic science, and other fields where sample characterization is required. ATR has several advantages over traditional transmission IR spectroscopy, including the requirement of little to no sample preparation and the ability to analyze a wide range of samples.
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Total Internal Reflection Fluorescence Microscopy01:05

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Total internal reflection fluorescence microscopy or TIRF is an advanced microscopic technique used to visualize fluorophores in samples close to a solid surface with a higher refractive index, such as a glass coverslip. TIRF only allows fluorophores in proximity to the solid surface to be excited. When light from a medium with a lower refractive index (such as air) hits the glass coverslip at a critical angle, the light undergoes total internal reflection stead of passing through the glass.
IR Spectrometers01:25

IR Spectrometers

There are two main infrared (IR) spectrophotometers: dispersive IR spectrometers and Fourier transform infrared (FTIR) spectrometers. In a dispersive IR spectrometer, a beam of infrared radiation produced by a hot wire is divided into two parallel equal-intensity beams using mirrors. One beam passes through the sample, while another is a reference beam. The beams then move through the monochromator, which separates the radiations into a continuous spectrum of different frequencies. The...

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Related Experiment Video

Updated: May 25, 2026

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb
06:50

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb

Published on: December 2, 2017

Non-contact time-resolved diffuse reflectance imaging at null source-detector separation.

M Mazurenka1, A Jelzow, H Wabnitz

  • 1Physikalisch-Technische Bundesanstalt, Abbestr. 2-12, 10587, Berlin, Germany. mikhail.mazurenka@ptb.de

Optics Express
|January 26, 2012
PubMed
Summary
This summary is machine-generated.

This study introduces a new non-contact tissue imaging system using advanced photon counting detectors. The system successfully detects buried optical absorbers in tissue-like materials, proving its feasibility for medical imaging.

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Related Experiment Videos

Last Updated: May 25, 2026

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06:50

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Published on: December 2, 2017

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Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy
09:25

Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy

Published on: August 22, 2018

Area of Science:

  • Biomedical Optics
  • Medical Imaging Technology
  • Photonics

Background:

  • Non-contact methods are crucial for safe and effective tissue imaging.
  • Time-domain near-infrared spectroscopy (TD-NIRS) offers potential for subsurface tissue analysis.
  • Limitations exist in current TD-NIRS systems regarding depth sensitivity and spatial resolution.

Purpose of the Study:

  • To demonstrate the proof-of-principle for a novel non-contact tissue imaging system.
  • To evaluate the system's capability in detecting optically absorbing perturbations within turbid media.
  • To assess the system's depth sensitivity and spatial resolution for diffuse reflectance measurements.

Main Methods:

  • Utilized a quasi-null source-detector separation approach for TD-NIRS.
  • Employed an innovative fast-gated single photon counting detector.
  • Conducted measurements on tissue-mimicking phantoms with embedded absorbing perturbations.

Main Results:

  • Successfully demonstrated the non-contact detection of absorbers buried up to a few centimeters deep.
  • Achieved depth sensitivity and spatial resolution comparable to Monte Carlo simulations.
  • Validated the feasibility of the non-contact approach for high-density diffuse reflectance measurements.

Conclusions:

  • The novel non-contact imaging system is feasible for detecting subsurface optical absorbers.
  • The system shows promise for advanced biomedical applications requiring non-invasive tissue analysis.
  • Further development could lead to significant advancements in medical diagnostics and imaging.