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Related Experiment Video

Updated: May 25, 2026

Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells
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Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells

Published on: July 24, 2014

Patterning embryos with oscillations: structure, function and dynamics of the vertebrate segmentation clock.

Andrew C Oates1, Luis G Morelli, Saúl Ares

  • 1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden, Germany. oates@mpi-cbg.de

Development (Cambridge, England)
|January 26, 2012
PubMed
Summary

The segmentation clock, a genetic network, controls embryonic development by rhythmically forming somites. New research clarifies its period regulation and anatomical impact, with future insights from real-time reporters and models.

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Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells
10:41

Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells

Published on: July 24, 2014

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11:52

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Published on: February 9, 2017

Area of Science:

  • Developmental biology
  • Genetics
  • Embryology

Background:

  • The segmentation clock is a key oscillating genetic network.
  • It regulates the rhythmic subdivision of the vertebrate embryonic body axis into somites.
  • Understanding its precise timing and patterning mechanisms remains a challenge.

Purpose of the Study:

  • To investigate the regulation of the segmentation clock's period.
  • To understand how period changes affect embryonic anatomy.
  • To explore future insights into the clock's dynamic behavior.

Main Methods:

  • Review of recent research findings.
  • Analysis of evidence on period regulation.
  • Consideration of real-time clock reporters and mathematical models.

Main Results:

  • Recent work has provided evidence for segmentation clock period regulation.
  • The regulation of the clock's period directly impacts embryonic anatomy.
  • Ongoing technological advancements promise deeper understanding.

Conclusions:

  • The segmentation clock is crucial for vertebrate somitogenesis.
  • Period regulation is a key factor influencing embryonic development.
  • Future research using advanced tools will illuminate clock dynamics.