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Updated: May 25, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
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3-Dimensional morphometric analysis of murine bladder development and dysmorphogenesis.

Ashley Carpenter1, Andrew Paulus, Melissa Robinson

  • 1Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205, USA. ashley.carpenter@nationwidechildrens.org

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|January 26, 2012
PubMed
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This summary is machine-generated.

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This study used 3-D analysis to examine mouse bladder development. Key findings reveal defects in detrusor smooth muscle and trigone morphology, impacting urinary tract development and potentially causing vesicoureteral reflux (VUR).

Area of Science:

  • Developmental Biology
  • Urology
  • Morphology

Background:

  • Urinary tract disorders cause significant morbidity and reduced quality of life.
  • Understanding normal urinary tract development is crucial for addressing congenital anomalies.
  • Mouse models are utilized to investigate complex developmental processes.

Purpose of the Study:

  • To investigate the morphological events during normal urinary tract development.
  • To analyze the impact of genetic mutations (mgb-/- and Fgfr2(Mes-/-)) on bladder development.
  • To identify morphological correlates of urinary tract dysfunction.

Main Methods:

  • Three-dimensional (3-D) reconstructive analysis of developing mouse bladders.
  • Comparative analysis of control, mgb-/-, and Fgfr2(Mes-/-) mouse models.

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Last Updated: May 25, 2026

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  • Multivariate morphometric analysis to quantify developmental changes.

    • Main Results:

    • Detrusor smooth muscle differentiation proceeds from the bladder dome caudally, with observed gender-specific differences.
    • Bladder trigone morphology evolves due to urethral-ureteral distance changes.
    • mgb-/- bladders showed reduced detrusor smooth muscle differentiation; Fgfr2(Mes-/-) trigone defects correlated with vesicoureteral reflux (VUR).

    Conclusions:

    • Multivariate morphometric analysis is effective for quantifying urinary tract development.
    • Specific morphological defects in mouse models provide insights into urinary tract disorders.
    • Understanding developmental morphology aids in diagnosing and potentially treating congenital urinary tract anomalies.