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Updated: May 25, 2026

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete
Published on: January 24, 2025
Secondary syphilis and HIV
Shagun Dhaliwal1, Mahir Patel, Alan Menter
1Texas A&M Health Science Center College of Medicine, Bryan, Texas (Dhaliwal), and the Division of Dermatology, Department of Internal Medicine, Baylor University Medical Center at Dallas (Patel, Menter).
Abstract:
Syphilis has been termed the "great mimic" due to its versatile and varied disease presentations. Dermatological findings are associated with the secondary phase of the disease and typically consist of a generalized papular eruption that can involve the palms and soles, genitals, and mucous membranes. Patients with syphilis and concomitant HIV infection may have altered presentations. We report a case of a 41-year-old HIV-positive man who presented with a papular rash of a few months' duration and was diagnosed with secondary syphilis.
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