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Topiramate and the vision: a systematic review
Mohammad-Ali Abtahi1, Seyed-Hossein Abtahi, Farhad Fazel
1Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
Clinical Ophthalmology (Auckland, N.Z.)
|January 26, 2012
Summary
Topiramate (TPM) can cause serious eye problems like glaucoma and vision changes. Neurologists and psychiatrists should monitor patients for these important ocular side effects.
Area of Science:
- Ophthalmology
- Neurology
- Pharmacology
Background:
- Topiramate (TPM) is a medication primarily used for epilepsy and migraine prevention.
- Ophthalmologic side effects are a significant concern associated with TPM use.
Purpose of the Study:
- To conduct the first systematic literature review on the ophthalmologic manifestations of Topiramate.
- To consolidate and analyze reported ocular side effects of TPM.
Main Methods:
- A PubMed search was conducted for studies on TPM's effects on vision from 1996 to 2011.
- 404 relevant citations were initially identified from 2756 TPM-related studies, with 74 ultimately reviewed.
Main Results:
- Ciliochoroidal effusion syndrome was the most frequent ocular side effect in 66 of 84 patients reviewed.
- This included 17 cases of myopic shift and 49 cases of angle closure glaucoma.
- Other rare effects included choroidal effusion, inflammatory reactions, visual field defects, and neuroophthalmologic complications.
Conclusions:
- Neurologists and psychiatrists must be aware of TPM's diverse ocular side effects given its expanding indications.
- Ocular complications from TPM require serious attention and prompt ophthalmic consultation.
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