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Bone metastasis from gynecologic carcinomas: a clinicopathologic study.
F W Abdul-Karim1, M Kida, W B Wentz
1Institute of Pathology, Department of Reproductive Biology, Case Western Reserve University, Cleveland, Ohio.
Gynecologic Oncology
|November 1, 1990
Summary
Skeletal metastases from gynecologic cancers are more common than previously thought, occurring in 16.1% of cases. These bone metastases correlate with advanced cancer stage and type.
Area of Science:
- Gynecologic Oncology
- Skeletal Pathology
- Cancer Metastasis
Background:
- Autopsies were performed on 305 patients with primary gynecologic carcinomas between 1948 and 1984.
- Skeletal metastases were detected in 49 cases (16.1%).
Purpose of the Study:
- To determine the incidence and sites of skeletal metastases from primary gynecologic carcinomas.
- To correlate these metastases with clinical and histopathologic classifications.
Main Methods:
- Retrospective analysis of autopsy data from 305 patients with primary gynecologic carcinomas.
- Correlation of skeletal metastasis data with clinical and histopathologic classifications.
Main Results:
- Skeletal metastases were detected in 16.1% of patients.
- The highest incidence was from cervical cancer (40.8%), followed by endometrial (34.7%), ovarian (14.3%), and vulvar (8.2%).
- No osseous metastases were found in vaginal carcinoma cases.
Conclusions:
- Osseous metastases from gynecologic carcinomas are not uncommon and are significantly greater than clinically appreciated.
- The incidence and sites of skeletal metastases correlate with advanced anatomic stage and histopathologic type and grade.