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Related Experiment Videos

Bone metastasis from gynecologic carcinomas: a clinicopathologic study.

F W Abdul-Karim1, M Kida, W B Wentz

  • 1Institute of Pathology, Department of Reproductive Biology, Case Western Reserve University, Cleveland, Ohio.

Gynecologic Oncology
|November 1, 1990
PubMed
Summary

Skeletal metastases from gynecologic cancers are more common than previously thought, occurring in 16.1% of cases. These bone metastases correlate with advanced cancer stage and type.

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Area of Science:

  • Gynecologic Oncology
  • Skeletal Pathology
  • Cancer Metastasis

Background:

  • Autopsies were performed on 305 patients with primary gynecologic carcinomas between 1948 and 1984.
  • Skeletal metastases were detected in 49 cases (16.1%).

Purpose of the Study:

  • To determine the incidence and sites of skeletal metastases from primary gynecologic carcinomas.
  • To correlate these metastases with clinical and histopathologic classifications.

Main Methods:

  • Retrospective analysis of autopsy data from 305 patients with primary gynecologic carcinomas.
  • Correlation of skeletal metastasis data with clinical and histopathologic classifications.

Main Results:

  • Skeletal metastases were detected in 16.1% of patients.

Related Experiment Videos

  • The highest incidence was from cervical cancer (40.8%), followed by endometrial (34.7%), ovarian (14.3%), and vulvar (8.2%).
  • No osseous metastases were found in vaginal carcinoma cases.

    • Conclusions:

    • Osseous metastases from gynecologic carcinomas are not uncommon and are significantly greater than clinically appreciated.
    • The incidence and sites of skeletal metastases correlate with advanced anatomic stage and histopathologic type and grade.