Thrombotic thrombocytopenic purpura. Clinical course and response to therapy in seven patients

The clinical characteristics, treatment and outcome are reported in 7 patients with 8 episodes of thrombotic thrombocytopenic purpura (TTP). In all episodes a complete remission was reached. Plasma exchange therapy was successful as single treatment in two episodes. Combination with other treatment modalities, however, was necessary in six episodes, in which a complete hematologic and clinical remission was obtained with antiplatelet therapy (4 X), and with antiplatelet therapy and corticosteroids (2 X).