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Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...

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Related Experiment Video

Updated: May 25, 2026

Rapid Determination of the Thermal Nociceptive Threshold in Diabetic Rats
05:45

Rapid Determination of the Thermal Nociceptive Threshold in Diabetic Rats

Published on: May 17, 2012

[Cutaneous thermographic changes in diabetic polyneuropathy].

Georgiana Mazilu1, C Filos, C D Popescu

  • 1Facultatea de Medicină, Universitatea de Medicină şi Farmacie "Gr.T. Popa", Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|January 27, 2012
PubMed
Summary

Thermography effectively detects early signs of peripheral polyneuropathy in diabetic patients, aiding in the prevention of foot ulcers. This method offers a valuable tool for diagnosing and monitoring patients with this condition.

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Rapid Determination of the Thermal Nociceptive Threshold in Diabetic Rats
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Area of Science:

  • Medical imaging
  • Neurology
  • Diabetology

Context:

  • Diabetic polyneuropathy is a common complication of diabetes mellitus.
  • Early detection of peripheral polyneuropathy is crucial for preventing serious complications like foot ulcers.
  • Traditional diagnostic methods may not always identify early-stage neuropathy.

Purpose:

  • To evaluate the effectiveness of thermography in diagnosing peripheral polyneuropathy in diabetic patients.
  • To assess the risk of developing ulcerative lesions in the feet of diabetic patients using thermography.
  • To establish thermography as a diagnostic and monitoring tool for diabetic polyneuropathy.

Summary:

  • A prospective study involving 90 patients (60 with type 2 diabetes and sensory-motor polyneuropathy, 30 controls) was conducted.
  • Thermography was used to measure skin temperature, revealing significantly reduced motor conduction velocity and altered skin temperatures in diabetic patients.
  • Results indicated that thermographic changes are early indicators of neuropathy and potential foot injury risk.

Impact:

  • Thermography can serve as an early detection method for peripheral polyneuropathy in diabetic individuals.
  • This imaging technique can aid in the prevention of plantar ulcerative lesions.
  • Thermography provides a valuable non-invasive tool for the diagnosis and ongoing evaluation of patients with diabetic sensory-motor polyneuropathy.