Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...

Spermatogenesis

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...

Infertility in Males

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

Anthelminthic Agents

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This makes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Magnesium, Zinc and Copper in Lung Fibrosis: A Narrative Review.

Medicina (Kaunas, Lithuania)·2026

Same author

The Relevance of Experimental Models in Assessing the Impact of Oxidative Stress on Intestinal Pathology.

Journal of clinical medicine·2025

Same author

Montelukast Influence on Lung in Experimental Diabetes.

Medicina (Kaunas, Lithuania)·2024

Same author

Montelukast influence on kidney in experimental induced diabetes mellitus.

Pakistan journal of pharmaceutical sciences·2023

Same author

Kaposi Sarcoma, a Trifecta of Pathogenic Mechanisms.

Diagnostics (Basel, Switzerland)·2022

Same author

Changes in Some Divalent Cations Concentrations In An Experimental Rat Model of Gentamicin-Induced Acute Renal Failure.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2018

Search research articles

Related Experiment Video

Updated: May 25, 2026

Two Types of Assays for Detecting Frog Sperm Chemoattraction

Two Types of Assays for Detecting Frog Sperm Chemoattraction

Published on: December 27, 2011

Pharmacological agents that affect sperm motility.

Elena Antohi¹, Cristina Gales, M Nechifor

¹"Gr. T. Popa" University of Medicine and Pharmacy Iasi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi

|January 27, 2012

Summary

This summary is machine-generated.

Antibiotics like ceftazidime and amoxicillin-clavulanic acid can negatively impact sperm motility in rats. Ceftazidime showed a more significant reduction in sperm motility compared to amoxicillin-clavulanic acid at tested doses.

Related Experiment Videos

Last Updated: May 25, 2026

Two Types of Assays for Detecting Frog Sperm Chemoattraction

Two Types of Assays for Detecting Frog Sperm Chemoattraction

Published on: December 27, 2011

Area of Science:

Reproductive toxicology
Pharmacology

Background:

Male fertility is crucial and influenced by sperm motility.
Numerous drugs can adversely affect sperm motility, necessitating investigation into common medications.

Purpose of the Study:

To evaluate the impact of specific antibacterial antibiotics on rat sperm motility.
To compare the effects of amoxicillin-clavulanic acid and ceftazidime on sperm motility.

Main Methods:

Rats were administered varying daily doses of amoxicillin-clavulanic acid or ceftazidime for 10-12 days.
Sperm motility was assessed, and histopathological examinations were conducted on harvested tissues.
A control group received no antibiotic treatment.

Main Results:

Amoxicillin-clavulanic acid significantly reduced sperm motility by 49.33% (30 mg/kg) and 68.96% (150 mg/kg).
Ceftazidime demonstrated a more pronounced reduction, decreasing sperm motility by 83.79% (50 mg/kg) and 85.36% (250 mg/kg).
All tested doses showed statistically significant reductions in sperm motility (p<0.01).

Conclusions:

Ceftazidime exhibits a potent negative effect on sperm motility at therapeutic doses.
The impact of ceftazidime on sperm motility is greater than that of amoxicillin-clavulanic acid.