Related Experiment Video

Updated: May 25, 2026

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples
13:21

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

Published on: May 4, 2012

[Keratin fragments as a serological indicator in patients with a liver disease]

J Lata1, H Mrlianová, O Stibůrek

  • 1Interní klinika Lékarské fakulty Ostravské univerzity a FN Ostrava. Jan.Lata@osu.cz

Vnitrni Lekarstvi
|January 27, 2012
PubMed
Abstract

Insights

M30 antigen is a sensitive indicator of liver damage, showing significant differences between patients and healthy controls. It strongly correlates with liver enzymes (ALT, AST) and tissue polypeptide-specific antigen (TPS), suggesting TPS may also indicate liver apoptosis.

Area of Science:

  • Hepatology
  • Biochemistry
  • Clinical Diagnostics

Context:

  • Hepatocyte apoptosis evaluation is crucial for understanding liver disease progression.
  • M30 antigen is recognized as a sensitive marker for assessing liver cell apoptosis.

Purpose:

  • To implement M30 antigen assessment for hepatocyte apoptosis.
  • To compare M30 levels in liver disease patients versus healthy controls.
  • To explore correlations between M30 values and clinical/laboratory parameters.

Summary:

  • M30 antigen levels were significantly different between liver disease patients (n=25) and healthy controls (n=30).
  • Significant correlations were observed between M30 and ALT, AST, and tissue polypeptide-specific antigen (TPS).
  • M30 serves as a sensitive indicator of liver damage, with TPS potentially indicating apoptosis in certain liver conditions.

Impact:

  • Establishes M30 antigen as a valuable tool for quantifying hepatocyte apoptosis in clinical settings.
  • Highlights the potential of TPS as a surrogate marker for apoptosis in liver disease.
  • Provides insights into the relationship between apoptosis markers and liver injury severity.

More Related Videos

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications09:29

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology12:36

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

Related Concept Videos

Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Liver Histology01:27

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...