Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Transient Ischemic Attack l: Introduction

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Coronary Artery Disease V: Interprofessional Care

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Untreated Hypertension and Subsequent Incidence of Colorectal Cancer: Analysis of a Nationwide Epidemiological Database.

Journal of the American Heart Association·2021

Same author

The five RADIANCE-HTN and SPYRAL-HTN randomised studies suggest that the BP lowering effect of RDN corresponds to the effect of one antihypertensive drug.

Blood pressure·2021

Same author

Reasons for Uncontrolled Blood Pressure Among US Adults: Data From the US National Health and Nutrition Examination Survey.

Hypertension (Dallas, Tex. : 1979)·2021

Same author

Factors Associated With Not Having a Healthcare Visit in the Past Year Among US Adults With Hypertension: Data From NHANES 2013-2018.

American journal of hypertension·2021

Same author

Combining proteomics, home blood pressure telemonitoring and patient empowerment to improve cardiovascular and renal protection.

Blood pressure·2021

Same author

Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2021

Same journal

Acute Left Heart Failure in Twin Pregnancies: Clinical Characteristics and Outcomes-A 10‑Year Retrospective Analysis of 24 Cases.

Journal of clinical hypertension (Greenwich, Conn.)·2026

Same journal

Visit-to-Visit Systolic Blood Pressure Variability Predicts Long-Term Cardiovascular Events After Coronary Artery Bypass Grafting.

Journal of clinical hypertension (Greenwich, Conn.)·2026

Same journal

Impact of Maternal Risk Stratification on Clinical Characteristics and Perinatal Outcomes in Singleton Pregnancies With Preeclampsia.

Journal of clinical hypertension (Greenwich, Conn.)·2026

Same journal

Antihypertensive Efficacy, Safety, and Adherence After Switching From a Free Combination of Bisoprolol/Metoprolol and Amlodipine to Bisoprolol/Amlodipine FDC Tablets (5/5 mg) in Chinese Patients With Hypertension.

Journal of clinical hypertension (Greenwich, Conn.)·2026

Same journal

Blood Pressure Variability in Acute Ischemic Stroke: Current Evidence, Measurement Challenges, and Future Directions.

Journal of clinical hypertension (Greenwich, Conn.)·2026

Same journal

Association of Triglyceride-Glucose Index, Triglyceride/HDL Cholesterol Ratio and Metabolic Score for Insulin Resistance With Asymptomatic Organ Damage in Previously Untreated Patients With Hypertension.

Journal of clinical hypertension (Greenwich, Conn.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 25, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Antiplatelet therapy for transient ischemic attack.

Maria Czarina Acelajado¹, Suzanne Oparil¹

¹From the Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL.

Journal of Clinical Hypertension (Greenwich, Conn.)

|January 27, 2012

Summary

This summary is machine-generated.

Transient ischemic attack (TIA) is a warning sign for stroke. Antiplatelet medications like aspirin and clopidogrel, or aspirin with extended-release dipyridamole, help prevent future strokes in TIA patients.

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Related Experiment Videos

Last Updated: May 25, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Area of Science:

Neurology
Vascular Medicine
Pharmacology

Background:

Transient ischemic attack (TIA) is a critical risk factor for subsequent stroke and major vascular events.
Effective management of TIA risk factors is essential for stroke prevention.
Current therapeutic strategies aim to mitigate the risk of stroke following a TIA.

Purpose of the Study:

To evaluate the efficacy of antiplatelet agents in the secondary prevention of stroke after TIA.
To compare the effectiveness of aspirin monotherapy, clopidogrel, and combination therapy with aspirin and extended-release dipyridamole.
To provide evidence-based recommendations for the initial management of patients with TIA.

Main Methods:

Review of existing literature on antiplatelet therapies for TIA and stroke.
Analysis of clinical trial data assessing the impact of aspirin (ASA), clopidogrel, and aspirin/extended-release dipyridamole combinations.
Comparative assessment of risk reduction and bleeding profiles for different therapeutic options.

Main Results:

Aspirin (50-325 mg/d) significantly reduces stroke risk post-TIA, stroke, or myocardial infarction.
Clopidogrel is an alternative for secondary prevention, though efficacy can be reduced in poor metabolizers.
Combination therapy with aspirin and extended-release dipyridamole demonstrates effectiveness in reducing TIA and stroke risk, potentially offering additional benefits over aspirin alone without increased bleeding.

Conclusions:

Aspirin monotherapy, clopidogrel monotherapy, and the combination of aspirin with extended-release dipyridamole are all viable initial treatment options for patients experiencing TIA.
The combination of aspirin and extended-release dipyridamole is recommended over aspirin monotherapy for patients with TIA due to its superior risk-lowering profile.
Further research may be needed to fully elucidate the role of aspirin in primary TIA/stroke prevention.