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Relationship between inflammation and microalbuminuria in prehypertension
J F Navarro-González1, C Mora, M Muros
1Nephrology Service, University Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain. jnavgon@gobiernodecanarias.org
Journal of Human Hypertension
|January 27, 2012
Summary
Inflammation markers like hs-CRP and TNF-α are linked to early kidney damage in prehypertension. These inflammatory factors may drive target-organ damage in individuals with elevated blood pressure.
Area of Science:
- Nephrology
- Cardiology
- Immunology
Background:
- Hypertension is a major risk factor for target-organ damage.
- Inflammation plays a key role in the pathogenesis of hypertension-related complications.
- Early detection of kidney damage in prehypertension is crucial.
Purpose of the Study:
- To investigate the association between inflammatory markers and urinary albumin excretion (UAE) in prehypertension.
- To identify inflammatory parameters as potential predictors of early kidney damage in prehypertensive individuals.
Main Methods:
- Cross-sectional study including 65 prehypertensive subjects and 26 healthy controls.
- Measurement of inflammatory markers: high-sensitivity C-reactive protein (hs-CRP), serum and urinary tumor necrosis factor-α (TNF-α).
- Assessment of urinary albumin excretion (UAE) to detect microalbuminuria (MAB).
Main Results:
- Prehypertensive subjects exhibited higher inflammatory markers and UAE compared to healthy controls.
- Serum hs-CRP and urinary TNF-α were elevated in prehypertensives with MAB.
- Systolic blood pressure, hs-CRP, and urinary TNF-α were independently correlated with UAE.
- hs-CRP and urinary TNF-α were independent risk factors for the presence of MAB in prehypertension.
Conclusions:
- Inflammatory parameters are significantly associated with UAE in prehypertension.
- Inflammation may contribute to early target-organ damage, specifically kidney damage, in prehypertensive individuals.
- Targeting inflammation could be a potential strategy for preventing cardiovascular and renal complications in prehypertension.
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