Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of an individualised nutritional intervention to tackle malnutrition in nursing homes: a pre-post study.

European geriatric medicine·2021
Same author

Nutritional status according to the mini nutritional assessment (MNA)® as potential prognostic factor for health and treatment outcomes in patients with cancer - a systematic review.

BMC cancer·2020
Same author

Comment on: Comparative characteristics of older people with type 1 diabetes treated with continuous subcutaneous insulin infusion or insulin injection therapy: data from the German/Austrian DPV registry. Reply to Rigalleau et al.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

Are Health Behaviors and Self-Rated Health Related to Cardiovascular Health and Functional Performance? Results from the Lookup 7+ Cross-Sectional Survey among Persons Aged 65+.

The journal of nutrition, health & aging·2020
Same author

Psychosocial aspects of diabetes technology.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

Comparative characteristics of older people with type 1 diabetes treated with continuous subcutaneous insulin infusion or insulin injection therapy: data from the German/Austrian DPV registry.

Diabetic medicine : a journal of the British Diabetic Association·2019
Same journal

[Journal Club].

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

Effect of anticholinergic burden on cardiac functions in older patients.

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

[Communication in later life under institutional conditions : Professional perspectives on communication of ageing people with profound intellectual and multiple disabilities].

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

Zeitschrift fur Gerontologie und Geriatrie·2026
See all related articles

Related Experiment Video

Updated: May 25, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

[Diabetes and dementia].

A Bahrmann1, P Bahrmann, T Kubiak

  • 1Medizinische Klinik 2, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland. anke.bahrmann@uk-erlangen.de

Zeitschrift Fur Gerontologie Und Geriatrie
|January 27, 2012
PubMed
Summary
This summary is machine-generated.

Diabetes mellitus increases the risk of cognitive dysfunction and dementia. This review covers the role of diabetes complications and therapy in dementia development.

More Related Videos

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Related Experiment Videos

Last Updated: May 25, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Area of Science:

  • Neuroscience
  • Endocrinology
  • Gerontology

Context:

  • Diabetes mellitus is a significant risk factor for cognitive decline and dementia.
  • Multiple factors contribute to cognitive dysfunction in diabetic patients, including hyperglycemia, genetics, hypertension, and depression.

Purpose:

  • To review the pathophysiology of diabetes and dementia.
  • To outline the key risk factors for cognitive dysfunction in diabetes.
  • To discuss diabetes management in patients with dementia.

Summary:

  • The review details how chronic hyperglycemia, genetic factors, hypertension, hyperlipoproteinemia, and vascular diseases contribute to cognitive impairment in diabetes.
  • It explores the underlying mechanisms connecting diabetes and dementia.
  • Specific therapeutic approaches for managing diabetes in individuals with dementia are presented.

Impact:

  • Provides a comprehensive overview of the relationship between diabetes and cognitive health.
  • Highlights critical risk factors for developing dementia in diabetic populations.
  • Informs clinical practice regarding diabetes management in patients with cognitive impairment.