[Psychosis in Parkinson's disease].
Arvid Rongve1, Eirik Auning, Uwe Ehrt
1Seksjon for alderspsykiatri, Klinikk for psykisk helsevern, Haugesund sykehus, Norway. arvid.rongve@helse-fonna.no
Summary
Psychosis is common in Parkinson's disease (PD), affecting up to 50% in later stages. While non-pharmacological methods show promise, clozapine remains the only documented effective drug, highlighting the need for new treatments.
Area of Science:
- Neurology
- Psychiatry
Context:
- Psychosis is a frequent and progressive complication in Parkinson's disease (PD).
- Management requires multidisciplinary specialist involvement alongside general practitioners.
Purpose:
- To review the prevalence, clinical presentation, etiology, and treatment of psychosis in Parkinson's disease.
Summary:
- Psychotic symptoms affect approximately 1% of newly diagnosed PD patients, rising to 50% in advanced stages, often with dementia.
- Visual disturbances like illusions and hallucinations are most common, though other sensory experiences occur.
- While non-pharmacological interventions are often effective, evidence is limited; clozapine is the sole antipsychotic with documented efficacy, yet easier-to-administer alternatives are needed.
Impact:
- Provides a comprehensive overview of PD-related psychosis for clinicians.
- Highlights the current treatment gap and the need for novel therapeutic strategies.
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