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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Pemphigus vegetans of the nose
Geoffrey A Sigmund1, Randy Oppenheimer
1Department of Radiology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Ear, Nose, & Throat Journal
|January 27, 2012
Summary
Pemphigus vegetans, a rare variant of pemphigus vulgaris, can affect the nose. This case highlights successful treatment of nasal pemphigus vegetans with high-dose prednisone.
Area of Science:
- Dermatology
- Autoimmune Blistering Diseases
Background:
- Pemphigus vulgaris is a rare autoimmune condition causing blistering of the skin and mucous membranes.
- Pemphigus vegetans is an uncommon subtype characterized by warty vegetations.
Observation:
- A 43-year-old woman presented with pemphigus vegetans affecting the nasal dorsum.
- The condition caused significant disfigurement of her external nose.
Findings:
- This presentation is unusual as head and neck pemphigus typically involves mucosal surfaces.
- The nasal dorsum is an atypical site for pemphigus vegetans.
Implications:
- This case expands the known clinical spectrum of pemphigus vegetans.
- It underscores the importance of considering unusual presentations in autoimmune blistering diseases.
- High-dose prednisone demonstrated efficacy in treating this rare nasal manifestation.
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